I am also very excited by DCA because of its potential cure for so many cancers and can be ordered online and best part is, not expensive. DCA has already been (safely) used on humans to treat mitochondrial/metabolic malfunctions and, considering that cancer is a mitochondrial malfunction, the doctor should be able to prescribe DCA to you as on "off-label" drug. The FDA allows medical doctors to prescribe drugs that have been used for one disease, to use against a different disease, if the physician feels that it is prudent and has a chance of working. There are also two testimonials of cancer patients with advance kidney cancer where DCA was used it as an adjuvant drug. There is also a testimonial from a Malaysian patient with breast cancer remission.
I would suggest that you visit this DCA site (for which most information of this post was derived from) for more detail information. I have extracted the key information for this post.
Dichloroacetic acid (DCA)
According to Wikipedia, Dichloroacetic acid, often abbreviated DCA, is the chemical compound with formula, CHCl2COOH. It is an acid, an analogue of acetic acid, in which two of the three hydrogen atoms of the methyl group have been replaced by chlorine atoms. The salt and esters of dichloroacetic acid are called dichloroacetates. Salts of DCA have been studied as potential drugs because they inhibit the enzyme pyruvate dehydrogenase kinase.
Cancel cells change the way they metabolize oxygen in a way that promotes their survival. In laboratory studies of isolated cancer cells grown in tissue culture, DCA restores the original metabolism, and promotes their self-destruction. This has led to the use of DCA for treating cancer, by individuals experimenting with it themselves, by doctors administering it to patients as a non-approved drug, by scientists testing it in cancer tissue cultures in cell culture and in mice, and in human Phase II studies. DCA has improved certain biochemical parameters, but it has not demonstrated improved survival.
A study in mice at the University of Alberta showed that "DCA induces apoptosis, decreases proliferation, and inhibits tumor growth, without apparent toxicity." In 2010, a small human trial on 5 cancer patients and 49 samples of tissue was conducted. The results were encouraging, and DCA "appeared to extend the lives of four of the five study participants".
How does DCA work, briefly?
The metabolic approach to cancer is supported by other research. Inhibition of Glycolysis in Cancer Cells: A Novel Strategy to Overcome Drug Resistance Associated with Mitochondrial Respiratory Defect and Hypoxia is a paper by a John Hopkins research team supporting this approach.
A team of researchers from University of Alberta, Canada studied the effects of DCA and published a paper called A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth. You can download a copy of the study here.
If you view the video from CTV you will see a jar of dichloroacetic acid prominently displayed. http://www.depmed.ualberta.ca/dca/vid1.htm is well worth watching. But they used a “cheap ...powder”. Dichloroacetic acid only comes in liquid. The powder is the sodium salt of dichloroacetic acid. It is sodium dichloroacetate. The researchers did not use the acid.
The half-life of DCA in the body is about 24 hours, so drug holidays are a good way to lower the levels of DCA and avoid side effects.
Side effects from DCA are reported even with doses of 13 to 14 mg/kg after 6 to 8 weeks. Considering the half-life of DCA (the amount of time necessary to metabolize and eliminate half of the DCA in one's system) can run as long as 24 hours, getting off DCA periodically might help keep the levels low and make managing side effects much easier. Good suggestions we hear include taking DCA every other day, or taking DCA Monday through Friday and not taking it on weekends.
DCA Safety and Side Effects
DCA is a common by-product of the chlorination of drinking water, and as a result, has been the focus of many studies. The EPA has published a large study, "Toxicological Review of Dichloroacetic Acid", a 200 plus page volume listing a summary of most DCA safety and health research done as of August 2003. WHO has published "Dichloroacetic Acid in Drinking Water", 2005. Health Canada has published "Haloacetic acids in Drinking Water" . This gives us an abundance of research to examine the safety considerations of DCA. (Please note that nowhere in the literature has any human ever been reported to have died from DCA intake)
"Dichloroacetic acid has been used as a therapeutic agent to treat lactic acidosis, diabetes, and familial hyperlipidaemia in humans; oral or intravenous therapeutic doses are usually in the range of 25–50 mg/kg of body weight per day (Stacpoole et al., 1998a)." WHO
NOEL: Stands for No Observed Effects Level
NOAEL is No Observed Adverse Effects Level
These levels are defined as the highest tested dose of a substance that has been reported to have no harmful (adverse) health effects on people or animals. Thanks to the extensive EPA research, the NOELs have been determined for mice, rats and dogs. These numbers range from 3 to 12.5 mg/kg.
"Several cases of mild peripheral neuropathy following dichloroacetic acid treatment at 50–100 mg/kg of body weight per day for several months to a year have been reported (Stacpoole et al., 1998a; Spruijt et al., 2001). All were completely reversible after cessation of treatment. In one of these cases, dichloroacetic acid was reinstituted at 25 mg/kg of body weight per day following reversal of neurological symptoms, and this dose was maintained for 2 years without further evidence of neuropathy (Stacpoole et al., 1998a). " WHO article.
The side effects reported by users (taken from our survey to-date), include:
- peripheral neuropathy (tingling in the fingers)
- numbness in toes or fingers
- shaking or tremors in hands
- weakness in legs
- mild nausea
- swollen ankles
- more urination
- breathing heavier than usual
- tingling (neuropathy) in the lips
Additionally, glutamine is something to consider. Dr. Steve Martin of Grouppe Kurosawa recommends 50g/day of glutamine.
"... natural treatments such as acetyl-L-carnitine, lipoic acid, evening primrose oil, fish oil, magnet therapy, selenium and vitamin E have been shown to alleviate the symptoms of diabetic neuropathy altogether" from http://www.peripheral-neuropathy-help.com/diabetic-neuropathy-treatment.html. It is interesting that most of these are known to be effective anti-cancer treatments.
Fish Oil supplementation has been shown to be effective. And taking fish oil is potentially a great supplement to take to fight cancer. Here is a reported remission due to fish oil.
Additionally there is talk that citric acid might help reduce peripheral neuropathy. One Dutch doctor self-medicating for his own cancer would take 20 grams of citric acid 20 minutes before taking before taking DCA.
According to the Washington Manual of Medical Therapeutics, the following cancers are associated with TLS:
- Non-Hodgkin's lymphoma (NHL)
- Acute lymphocytic leukemia (ALL)
- Acute myelocytic leukemia (AML)
- Chronic lymphocytic leukemia (CLL)
- Chronic myelocytic leukemia (CML)
- Breast cancer
- Testicular cancer
- Merkel cell carcinoma
- Small cell carcinoma of the lung
1. See your doctor immediately
2. Discontinue use of DCA until the symptoms subside,
3. When you start taking DCA again, use it at a lower dose or use DCA on alternate days.