My hypnotherapist has advised me to consider changing the cimetidine drug to omeprazole as replacement as taking cimetidine on long terms basis could lead to dementia. From documentation, omerprazole has better results than cimetidine for traditional treatment of prepyloric gastric ulcers. Here, I am talking about using the drug as a cancer drug. Can a replacement have the same result?
Histamine is the chemical (neuro-transmitter) your body produces when you're having an allergic reaction. Although there is always some histamine in your body, a mosquito bite (for example), causes your body to release more histamine in the area of the bite, making your skin red and itchy. In extreme cases, histamine levels in someone who is allergic to a bee sting or a particular food like strawberries can be elevated so high that it causes anaphylactic shock and possibly death. Adrenaline (Epinephrine) is the only chemical that can quickly eliminate histamine in a person. So called "antihistamines" like Benadryl only work to block some of your body's histamine receptors (relieving some histamine related symptoms), they do not remove histamine. If you do go into anaphylactic shock (where your organs essentially shut down), it is essential that you are injected with adrenaline immediately to counteract the dangerously high histamine level and prevent death.
Cancer cells like histamine. To a cancer cell histamine is food. There are histamine-receptor antagonists other than cimetidine: ranitidine, nizatidine, famotidine. These had not been studied in the same way as cimetidine and in 1996 the University of New South Wales Department of Surgery team conducted an investigation to see if ranitidine, marketed as Zantac and the biggest selling drug of all time, also inhibited tumour growth in laboratory cancer cell lines and in laboratory mice. They found that where cimetidine did inhibit cell growth, ranitidine had no effect. This was confirmed and enlarged upon by a similar study from the Ajou Institute for Medical Science, Suwon, Korea where the possible anticancer effects of ranitidine and famotidine were studied. In this study rantidine had a slight effect that didn't reach statistical significance, while famotidine had no effect at all.
The point is not all histamine-receptor antagonists are made alike. What more, we are using the drug for treatment of cancer, not the original purpose for which the drug was designed for.
At the moment, I am still looking for evidence that omerprazole is as effective as cimetidine in cancer therapy. A study published by the Gastroenterology Research Group shows that omeprazole has a cytostatic effect on one (NCI-H716) of three colorectal cancer cell lines but the mechanism for this effect of omeprazole and its potential role in treatment awaits elucidation.